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Sickle Cell Therapy With CRISPR Gene Editing Shows Promise

by Cathy Drummond

Contributing Writer for Telegraph Local

Sickle Cell Therapy with CRISPR gene editing shows promise. “CRISPR” is announced Crisper. CRISPR is a technique in which genes are “modified” or edited to change DNA sequences according to Live Science . Considered controversial, genome editing (gene editing), according to some, has proven to be very effective thus far. Especially telling in the current trials involving Sickle Cell Therapy.

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CRISPR is acronym for Clustered Regularly Interspaced Short Palindromic Repeats according to the Broad Institute  CRISPR has proven to be very effective in the treatment of Sickle Cell. Sickle Cell is short for the term Sickle cell anemia. Sickle Cell is a proven blood disorder which primarily affects African Americans.

According to the Mayo Clinic sickle cell anemia happens when the normal round blood cell looks like a sickle. Sickle cell anemia is an inherited form of anemia. Anemia occurs when red blood cells are inadequate to carry the needed oxygen in the body. The red blood cell becomes “sticky,” hard, or “rigid.” The ill-formed shapes (sickles) can get intertangled, or “stuck” in small blood vessel. Getting stuck in these small blood vessels will block or interfere with the flow of oxygen through these small blood vessels. The transmission of Sickle Cell anemia also involves pain, or periods of crisis. This pain reflects periods when the odd shaped red blood cells have interfered with the flow of blood through the tiniest blood vessels. Normally shaped red blood is unable sufficiently flow throughout the bones, the abdomen, one’s chest, and even one’s joint.

Recent Sickle Cell Therapy has proven very effective. However, controversy exists in the present CRISPR Sickle Cell Therapy treatment. Controversial in terms of the ethics being attached to editing the genome, DNA. However, the reported success of present subjects such as Victoria Gray, Janelle Stephenson, and Lynndrick Holmes seemed to help overcome any misgivings some have felt because of these purported ethical concerns.

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Sickle Cell Therapy has continued to show promise in the treatment of Sickle Cell Anemia. CRISPR (clustered regularly interspaced short palindromic repeats,) pronounced (crisper), has proven the most effective in the treatment of Sickle Cell Anemia. And the subjects previously mentioned in this article can be seen as beacons in the fight against this debilitating form of anemia. And even though this form of blood cell anemia affects approximately 100,000 Americans, primarily African American according to the CDC.

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